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Chronic granulomatous disease: why an inflammatory disease? BJMBR
Roxo-Junior,P.; Simão,H.M.L..
Chronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions. Among the latter, inflammatory manifestations are predominant, especially granulomas and colitis. In this article, we systematically review the possible mechanisms of hyperinflammation in this rare primary immunodeficiency condition and their correlations with clinical aspects.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic granulomatous disease; Inflammation; Infection; Granulomas; NADPH oxidase.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100924
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Histopathological findings in lungs of hawksbill turtles collected on the coasts of the states of Espírito Santo and Rio de Janeiro, Brazil Arq. Bras. Med. Vet. Zootec.
Silva,M.A.; Jerdy,H.L.; Ribeiro,R.B.; Medina,R.M.; Petronilha,M.B.R.G.; Shimoda,E.; Werneck,M.R.; Andrade,J.G.; Carvalho,E.C.Q..
ABSTRACT The present work aimed to report the histopathological findings verified in lungs of hawksbill turtles (Eretmochelys imbricata) retrieved from the coasts of the states of Espírito Santo and Rio de Janeiro, Brazil. Between the years 2010 and 2014, 29 E. imbricata individuals were found stranded on the coasts, already dead or dying during treatment. Lung samples of all specimens were collected during necropsies, fixed in 10% neutral buffered formalin, subjected to routine histological processing and classified histomorphologically. The findings revealed that 37.93% of the specimens presented lung lesions. Of these, 90.91% were rescued alive and 9.09% were found dead; 63.63% were females and 36.37% were males. The mean weight was 5.44 Kg and the mean...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pneumonia; Eretmochelys imbricata; Granulomas.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000501267
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